A mixture theory is developed for multi-component micropolar porous media with a combination of the hybrid mixture theory and the micropolar continuum theory. The system is modeled as multi-component micropolar elastic solids saturated with multicomponent micropolar viscous fluids. Balance equations are given through the mixture theory. Constitutive equations are developed based on the second law of thermodynamics and constitutive assumptions. Taking account of compressibility of solid phases, the volume fraction of fluid as an independent state variable is introduced in the free energy function, and the dynamic compatibility condition is obtained to restrict the change of pressure difference on the solid-fluid interface. The constructed constitutive equations are used to close the field equations. The linear field equations are obtained using a linearization procedure, and the micropolar thermo-hydro-mechanical component transport model is established. This model can be applied to practical problems, such as contaminant, drug, and pesticide transport. When the proposed model is supposed to be porous media, and both fluid and solid are single-component, it will almost agree with Eringen’s model.