Abstract: The mechanism of the response motion of a suspended particle to turbulent motion of its surrounding fluid is different according to si:e of turbulent eddies. The particle is dragged by the viscous force of large eddies, and meanwhile driven randomly by small eddies. Based on this understanding, the dispersion of a particle with finite size in a homogeneous isotropic turbulence is calculated in this study. Results show that there are two competing effects: when enhanced by the inertia of a particle, the long-term particle diffusivity is reduced by the finite size of the particle.