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Applied Mathematics and Mechanics (English Edition) ›› 2004, Vol. 25 ›› Issue (4): 440-444.

• 论文 • 上一篇    下一篇

METHOD ON ESTIMATION OF DRUG’S PENETRATED PARAMETERS

刘宇红1, 曾衍钧1, 许景锋2, 张梅2   

  1. 1. Biomechanical and Medical Information Institute, Beijing Polytechnic University, Beijing 100022, P. R. China;
    2. Beijing Military Command Clinical Pharmaceutical Institute, Beijing 100700, P. R. China
  • 收稿日期:2001-11-27 修回日期:2003-12-02 出版日期:2004-04-18 发布日期:2004-04-18
  • 通讯作者: ZENG Yan-jun(Corresponding author,Tel:+86-10-67391685;Fax:+86-10-67391610;E-mail:yjzeng@bjpu.edu.cn) E-mail:yjzeng@bjpu.edu.cn

METHOD ON ESTIMATION OF DRUG’S PENETRATED PARAMETERS

LIU Yu-hong1, ZENG Yan-jun1, XU Jing-feng2, ZHANG Mei2   

  1. 1. Biomechanical and Medical Information Institute, Beijing Polytechnic University, Beijing 100022, P. R. China;
    2. Beijing Military Command Clinical Pharmaceutical Institute, Beijing 100700, P. R. China
  • Received:2001-11-27 Revised:2003-12-02 Online:2004-04-18 Published:2004-04-18

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摘要： Transdermal drug delivery system (TDDS) is a new method for drug delivery. The analysis of plenty of experiments in vitro can lead to a suitable mathematical model for the description of the process of the drug’s penetration through the skin, together with the important parameters that are related to the characters of the drugs.After the research work of the experiments data,a suitable nonlinear regression model was selected. Using this model, the most important parameter-penetrated coefficient of 20 drugs was computed.In the result one can find, this work supports the theory that the skin can be regarded as singular membrane.

Abstract: Transdermal drug delivery system (TDDS) is a new method for drug delivery. The analysis of plenty of experiments in vitro can lead to a suitable mathematical model for the description of the process of the drug’s penetration through the skin, together with the important parameters that are related to the characters of the drugs.After the research work of the experiments data,a suitable nonlinear regression model was selected. Using this model, the most important parameter-penetrated coefficient of 20 drugs was computed.In the result one can find, this work supports the theory that the skin can be regarded as singular membrane.

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