Applied Mathematics and Mechanics (English Edition) ›› 2017, Vol. 38 ›› Issue (10): 1481-1496.doi: https://doi.org/10.1007/s10483-017-2251-6

• 论文 • 上一篇    

Transfer characteristics of dynamic biochemical signals in non-reversing pulsatile flows in a shallow Y-shaped microfluidic channel:signal filtering and nonlinear amplitude-frequency modulation

Zongzheng CHEN, Weimo YUAN, A. R. AZIZ, Zhengming GAO, Depei ZENG, Bo LIU, Kairong QIN   

  1. Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, China
  • 收稿日期:2017-03-23 修回日期:2017-04-27 出版日期:2017-10-01 发布日期:2017-10-01
  • 通讯作者: Kairong QIN E-mail:krqin@dlut.edu.cn
  • 基金资助:

    Project supported by the National Natural Science Foundation of China (Nos. 11172060 and 11672065)

Transfer characteristics of dynamic biochemical signals in non-reversing pulsatile flows in a shallow Y-shaped microfluidic channel:signal filtering and nonlinear amplitude-frequency modulation

Zongzheng CHEN, Weimo YUAN, A. R. AZIZ, Zhengming GAO, Depei ZENG, Bo LIU, Kairong QIN   

  1. Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, China
  • Received:2017-03-23 Revised:2017-04-27 Online:2017-10-01 Published:2017-10-01
  • Contact: Kairong QIN E-mail:krqin@dlut.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 11172060 and 11672065)

摘要:

The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are analyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.

关键词: fracture, internal parallel crack, criterion of the initiation of fracture, Taylor-Aris dispersion, nonlinear amplitude-frequency modulation, shallow Y-shaped microfluidic channel, dynamic biochemical signal, nonreversing pulsatile flow

Abstract:

The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are analyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.

Key words: fracture, internal parallel crack, criterion of the initiation of fracture, nonreversing pulsatile flow, dynamic biochemical signal, Taylor-Aris dispersion, shallow Y-shaped microfluidic channel, nonlinear amplitude-frequency modulation

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