Abstract: The general Brusselator system is considered under homogeneous Neumann boundary conditions. The existence results of the Hopf bifurcation to the ordinary differential equation (ODE) and partial differential equation (PDE) models are obtained. By the center manifold theory and the normal form method, the bifurcation direction and stability of periodic solutions are established. Moreover, some numerical simulations are shown to support the analytical results. At the same time, the positive steady-state solutions and spatially inhomogeneous periodic solutions are graphically shown to supplement the analytical results.