A method for combining the CFD software, Fluent, with the iSIGHT design platform is presented to optimize a three-dimensional wing to ameliorate its aerodynamics performance. In the optimization design, two kinds of genetic algorithms, the Neighborhood Cultivation Genetic Algorithm (NCGA) and the Non-dominated Sorting Genetic Algorithm (NSGAII), are employed and the Navier-Stoke (N-S) equations are adopted to derive the aerodynamics functions of the 3D wing. The aerodynamic performance of the optimized wing has been significantly improved, which shows that the approach can be extended and employed in other cases.