Based on the Hellinger-Reissner (H-R) mixed variational principle for piezoelectric material, a unified 4-node Hamiltonian isoparametric element of anisotropy piezoelectric material is established. A new semi-analytical solution for the natural vibration of smart laminated plates and the transient esponse of the laminated cantilever with piezoelectric patch is presented. The major steps of mathematical model are as follows: the piezoelectric layer and host layer of laminated plate are considered as unattached three-dimensional bodies and discretized by the Hamiltonian isoparametric elements. The control equation of whole structure is derived by considering the compatibility of generalized displacements and generalized stresses on the interface between layers. There is no restriction for the side-face geometrical boundaries, the thickness and the number of layers of plate by the use of the present isoparametric element. Present method has wide application area.