The three-dimension gas-particle flow in a spiral cyclone is simulated numerically in this paper. The gas flow field was obtained by solving the three-dimension Navier-Stokes equations with Reynolds Stress Model (RSM). It is shown that there are two regions in the cyclone, the steadily tangential flow in the spiral channel and the combined vortex flow in the centre. Numerical results for particles trajectories show that the initial position of the particle at the inlet plane substantially affects its trajectory in the cyclone. The particle collection efficiency curves at different inlet velocities were obtained and the effects of inlet flow rate on the performance of the spiral cyclone were presented. Numerical results also show that the increase of flow rate leads to the increase of particles collection efficiency, but the pressure drop increases sharply.