Common effect of wave and slip of internal vehicles will make rolling of the roll-on ship serious. This is one of the important reasons for overturn of ro-ro ships. The multibody system with a floating base is composed of ro-ro ship and slipping vehicles. Takes the rolling angle of the ship and the transverse displacements of the slipping vehicles on desk as freedoms. Making use of the analysis of apparent gravitation and apparent buoyancy, the wave rolling moment is derived. By means of dynamic method of multibody system, dynamic equations of the system are established. Taking a certain channel ferry as an example, a set of numerical calculation have been carried out for rolling response of the multibody system with a floating base of a ro-ro ship and displacements response of the slipping vehicles under common effect of free slipping vehicles and wave, and a conclusion has been drawn that the motion of the numerous free slipping heavy loads will trend to be synchronous under restraining of the side-wall bulkhead with time because of repeated collision.