The unsteady oscillatory flow of an incompressible second grade fluid in a cylindrical tube with large wall suction is studied analytically. Flow in the tube is due to uniform suction at the permeable walls, and the oscillations in the velocity field are due to small amplitude time harmonic pressure waves. The physical quantities of interest are the velocity field, the amplitude of oscillation, and the penetration depth of the oscillatory wave. The analytical solution of the governing boundary value problem is obtained, and the effects of second grade fluid parameters are analyzed and discussed.