Magnetic nanoparticle drug targeting to patient-specific atherosclerosis: effects of magnetic field intensity and configuration

Xuelan ZHANG, Mingyao LUO, Peilai TAN, Liancun ZHENG, Chang SHU

doi:10.1007/s10483-020-2566-9

2020 , Vol. 41 >Issue 2: 349 - 360

DOI: https://doi.org/10.1007/s10483-020-2566-9

Articles

Magnetic nanoparticle drug targeting to patient-specific atherosclerosis: effects of magnetic field intensity and configuration

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1. School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China;
2. School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China;
3. Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

Received date: 2019-06-14

Revised date: 2019-10-24

Online published: 2020-01-03

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 11772046 and 81870345)

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Abstract

Nanoparticle-mediated drug delivery is recognized as a promising option for targeted treatment of atherosclerosis. In this paper, the Eulerian-Lagrangian technique is adopted to simulate the delivery of drug-loaded nanoparticles to patient-specific atherosclerotic plaque with the aid of an external magnetic field. Plaques and vascular walls are introduced as porous media formulated by the Darcy-Forchheimer model in this targeted transport process. The results demonstrate that the delivery efficiency of particles to atherosclerosis depends on the external magnetic field, such as configuration and intensity, in which the configuration angle of the current wire is a key factor and the double current wires have advantages over the single current wire. Meanwhile, the delivery efficiency gradually decreases as the distance between the plaque cap and the current wire increases. Further, although augmenting the current or magnetic susceptibility can generally improve the delivery efficiency of nanoparticles, this increase is not apparent when small-sized nanoparticles are employed as drug transport particles. The results obtained can potentially serve as the guideline to optimize regimens for the targeted therapy of atherosclerosis.

Key words： atherosclerosis; nanoparticle-mediated drug delivery; magnetic field; targeted delivery efficacy; computational fluid dynamics

Cite this article

Xuelan ZHANG, Mingyao LUO, Peilai TAN, Liancun ZHENG, Chang SHU . Magnetic nanoparticle drug targeting to patient-specific atherosclerosis: effects of magnetic field intensity and configuration[J]. Applied Mathematics and Mechanics, 2020 , 41(2) : 349 -360 . DOI: 10.1007/s10483-020-2566-9

References

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