Articles

Piezoelectric and flexoelectric effects of DNA adsorbed films on microcantilevers

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  • 1. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai Key Laboratory of Mechanics in Energy Engineering, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China;
    2. School of Mechanical Engineering and Rail Transit, Changzhou University, Changzhou 213164, Jiangsu Province, China

Received date: 2023-01-21

  Revised date: 2023-06-05

  Online published: 2023-08-28

Supported by

Project supported by the National Natural Science Foundation of China (Nos.12172204, 11772182, 11272193, and 10872121), the Program of Shanghai Municipal Education Commission (No.2019-01-07-00-09-E00018), and the Natural Science Foundation of Shanghai (No.22Z00142)

Abstract

DNA-based biosensors have played a huge role in many areas, especially in current global coronavirus outbreak. However, there is a great difficulty in the characterization of piezoelectric and flexoelectric coefficients of the nanoscale DNA film, because the existing experimental methods for hard materials are almost invalid. In addition, the relevant theoretical models for DNA films only consider a single effect without clarifying the difference between the two electromechanical effects on device detection signals. This work aims to present multiscale models for DNA-microcantilever experiments to clarify the competitive mechanism in piezoelectric and flexoelectric effects of DNA films on detection signals. First, a Poisson-Boltzmann (PB) equation is used to predict the potential distribution due to the competition between fixed phosphate groups and mobile salt ions in DNA films. Second, a macroscopic piezoelectric/flexoelectric constitutive equation of the DNA film and a mesoscopic free energy model of the DNA solution are combined to analytically predict the electromechanical coefficients of the DNA film and the relevant microcantilever signals by the deformation equivalent method and Zhang's two-variable method. Finally, the effects of detection conditions on microscopic interactions, electromechanical coupling coefficients, and deflection signals are studied. Numerical results not only agree well with the experimental observations, but also reveal that the piezoelectric and flexoelectric effects of the DNA film should be equivalently modeled when interpreting microcantilever detection signals. These insights might provide opportunities for the microcantilever biosensor with high sensitivity.

Cite this article

Yuan YANG, Nenghui ZHANG, Hanlin LIU, Jiawei LING, Zouqing TAN . Piezoelectric and flexoelectric effects of DNA adsorbed films on microcantilevers[J]. Applied Mathematics and Mechanics, 2023 , 44(9) : 1547 -1562 . DOI: 10.1007/s10483-023-3026-5

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