Morphology of cylindrical cell sheets with embedded contractile ring

doi:10.1007/s10483-019-2544-8

摘要/Abstract

摘要： The behavior of large deformations of cellular tissues is usually affected by the local properties of cells and their interactions, resulting in folding which acts as an important role in the embryonic development, as well as growing and spreading of a tumor, which can rapidly promote the stereo complexity of the architecture of the tissues. In the present study, a cylindrical vertex model is constructed to explore the morphology of the tubular cell sheets subject to an embedded contractile ring. It is found that an inner region of the contractile ring in equilibrium will protrude from the tube wall, and it will suddenly collapse when the contractile strength exceeds a threshold, indicating the occurrence of a bifurcation. These results on the effect of embedded contraction in the tubular shell are quite different from the planar cases, which can reveal the importance of the interaction between the geometric and material non-linearity in cylindrical geometry. The dependence of the large deformation on the bending modulus parameters and contraction strength is also analyzed for the cylindrical cell shell.

关键词: vertex model, cylindrical cell sheet, contractile ring, large deformation, protrusion

Abstract: The behavior of large deformations of cellular tissues is usually affected by the local properties of cells and their interactions, resulting in folding which acts as an important role in the embryonic development, as well as growing and spreading of a tumor, which can rapidly promote the stereo complexity of the architecture of the tissues. In the present study, a cylindrical vertex model is constructed to explore the morphology of the tubular cell sheets subject to an embedded contractile ring. It is found that an inner region of the contractile ring in equilibrium will protrude from the tube wall, and it will suddenly collapse when the contractile strength exceeds a threshold, indicating the occurrence of a bifurcation. These results on the effect of embedded contraction in the tubular shell are quite different from the planar cases, which can reveal the importance of the interaction between the geometric and material non-linearity in cylindrical geometry. The dependence of the large deformation on the bending modulus parameters and contraction strength is also analyzed for the cylindrical cell shell.

Key words: vertex model, cylindrical cell sheet, contractile ring, large deformation, protrusion

中图分类号:

92C10
92C05

Nan NAN, Guohui HU. Morphology of cylindrical cell sheets with embedded contractile ring[J]. Applied Mathematics and Mechanics (English Edition), 2019, 40(12): 1847-1860.

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