Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit

doi:10.1007/s10483-020-2644-8

Applied Mathematics and Mechanics (English Edition) ›› 2020, Vol. 41 ›› Issue (9): 1287-1302.doi: https://doi.org/10.1007/s10483-020-2644-8

• 论文 • 下一篇

Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit

Denggui FAN¹, Yanhong ZHENG², Zecheng YANG¹, Qingyun WANG³

1. School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China;
2. College of Mathematics and Informatics, Fujian Normal University, Fuzhou 350117, China;
3. Department of Dynamics and Control, Beihang University, Beijing 100191, China

收稿日期:2020-03-13 修回日期:2020-05-28 出版日期:2020-09-01 发布日期:2020-08-27
通讯作者: Qingyun WANG E-mail:nmqingyun@163.com
基金资助:
Project supported by the National Natural Science Foundation of China (Nos. 11702018, 11932003, and 11672074)

Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit

Denggui FAN¹, Yanhong ZHENG², Zecheng YANG¹, Qingyun WANG³

1. School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China;
2. College of Mathematics and Informatics, Fujian Normal University, Fuzhou 350117, China;
3. Department of Dynamics and Control, Beihang University, Beijing 100191, China

Received:2020-03-13 Revised:2020-05-28 Online:2020-09-01 Published:2020-08-27
Contact: Qingyun WANG E-mail:nmqingyun@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 11702018, 11932003, and 11672074)

摘要/Abstract

摘要： Presently, we develop a simplified corticothalamic (SCT) model and propose a single-pulse alternately resetting stimulation (SARS) with sequentially applying anodic (A, “+”) or cathodic (C, “-”) phase pulses to the thalamic reticular (RE) nuclei, thalamus-cortex (TC) relay nuclei, and cortical excitatory (EX) neurons, respectively. Abatement effects of ACC-SARS of RE, TC, and EX for the 2 Hz–4 Hz spike and wave discharges (SWD) of absence seizures are then concerned. The m:n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption. In particular, when its frequency is out of the 2 Hz–4 Hz SWD dominant rhythm, the desired seizure abatements can be obtained, which can be further improved by our proposed directional steering (DS) stimulation. The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate (AMFR) of neurons and triggering averaged mean firing rates (TAMFRs) of 2 Hz–4 Hz SWD.

关键词: epileptic absence seizure, spike and wave discharge (SWD), single-pulse alternately resetting stimulation (SARS), mean field model, averaged mean firing rate (AMFR), seizure control

Abstract: Presently, we develop a simplified corticothalamic (SCT) model and propose a single-pulse alternately resetting stimulation (SARS) with sequentially applying anodic (A, “+”) or cathodic (C, “-”) phase pulses to the thalamic reticular (RE) nuclei, thalamus-cortex (TC) relay nuclei, and cortical excitatory (EX) neurons, respectively. Abatement effects of ACC-SARS of RE, TC, and EX for the 2 Hz–4 Hz spike and wave discharges (SWD) of absence seizures are then concerned. The m:n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption. In particular, when its frequency is out of the 2 Hz–4 Hz SWD dominant rhythm, the desired seizure abatements can be obtained, which can be further improved by our proposed directional steering (DS) stimulation. The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate (AMFR) of neurons and triggering averaged mean firing rates (TAMFRs) of 2 Hz–4 Hz SWD.

Key words: epileptic absence seizure, spike and wave discharge (SWD), single-pulse alternately resetting stimulation (SARS), mean field model, averaged mean firing rate (AMFR), seizure control

中图分类号:

Denggui FAN, Yanhong ZHENG, Zecheng YANG, Qingyun WANG. Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit[J]. Applied Mathematics and Mechanics (English Edition), 2020, 41(9): 1287-1302.

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Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit

Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit

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