Abstract: For the first time. the pressure and flow pulse wave propagation phenomenon isstudied in this paper on the basis of the cardiovascular dynamic coupling. E(l)-R modelis adopted for left ventricle and T-Y tube model for systemic arteries. Furthermore,impulse response method and Fourier analysis method are employed. After reasonablecardiovascular parameters and their value have been selected, the pressure and flowwaveforms are obtained at any poing along the systemic arteries. The results fitmeasured data well. In addition, the influences of cardiovascular parameters on pulsewave propagation are studied. The work is useful in practice.