MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX

Applied Mathematics and Mechanics (English Edition) ›› 2001, Vol. 22 ›› Issue (4): 379-384.

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MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX

谭文长, 吴望一, 严宗毅, 温功碧

Department of Mechanics and Engineering Science, Peking University, Beijing 100871, P R China

收稿日期:1999-09-03 修回日期:2000-11-09 出版日期:2001-04-18 发布日期:2001-04-18
基金资助:
the National Natural Science Foundation of China(10002003);Foundation for University Key Teacher by the Ministry of Education

MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX

TAN Wen-chang, WU Wang-yi, YAN Zong-yi, WEN Gong-bi

Department of Mechanics and Engineering Science, Peking University, Beijing 100871, P R China

Received:1999-09-03 Revised:2000-11-09 Online:2001-04-18 Published:2001-04-18
Supported by:
the National Natural Science Foundation of China(10002003);Foundation for University Key Teacher by the Ministry of Education

摘要/Abstract

摘要： An approximate analytical solution of moving boundary problem for diffusion release of drug from a cylinder polymeric matrix was obtained by use of refined integral method. The release kinetics has been analyzed for non-erodible matrices with perfect sink condition. The formulas of the moving boundary and the fractional drug release were given. The moving boundary and the fractional drug release have been calculated at various drug loading levels, and the calculated results were in good agreement with those of experiments. The comparison of the moving boundary in spherical, cylinder, planar matrices has been completed. An approximate formula for estimating the available release time was presented. These results are useful for the clinic experiments. This investigation provides a new theoretical tool for studying the diffusion release of drug from a cylinder polymeric matrix and designing the controlled released drug.

Abstract: An approximate analytical solution of moving boundary problem for diffusion release of drug from a cylinder polymeric matrix was obtained by use of refined integral method. The release kinetics has been analyzed for non-erodible matrices with perfect sink condition. The formulas of the moving boundary and the fractional drug release were given. The moving boundary and the fractional drug release have been calculated at various drug loading levels, and the calculated results were in good agreement with those of experiments. The comparison of the moving boundary in spherical, cylinder, planar matrices has been completed. An approximate formula for estimating the available release time was presented. These results are useful for the clinic experiments. This investigation provides a new theoretical tool for studying the diffusion release of drug from a cylinder polymeric matrix and designing the controlled released drug.

中图分类号:

O29
TB11

谭文长;吴望一;严宗毅;温功碧. MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX[J]. Applied Mathematics and Mechanics (English Edition), 2001, 22(4): 379-384.

TAN Wen-chang;WU Wang-yi;YAN Zong-yi;WEN Gong-bi. MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX[J]. Applied Mathematics and Mechanics (English Edition), 2001, 22(4): 379-384.

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MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX

MOVING BOUNDARY PROBLEM FOR DIFFUSION RELEASE OF DRUG FROM A CYLINDER POLYMERIC MATRIX

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