Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

doi:10.1007/s10483-023-2986-7

Applied Mathematics and Mechanics (English Edition) ›› 2023, Vol. 44 ›› Issue (5): 823-840.doi: https://doi.org/10.1007/s10483-023-2986-7

Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

J.Y. LIANG¹, Wenjuan YAO^2,3

1. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, U.S.A.;
2. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China;
3. School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China

收稿日期:2022-12-25 修回日期:2023-02-28 发布日期:2023-04-24
通讯作者: Wenjuan YAO, E-mail: wenjuan@mail.shu.edu.cn
基金资助:
the Key Projects of National Natural Science Foundation of China (No.11932010)

Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

J.Y. LIANG¹, Wenjuan YAO^2,3

1. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, U.S.A.;
2. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China;
3. School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China

Received:2022-12-25 Revised:2023-02-28 Published:2023-04-24
Contact: Wenjuan YAO, E-mail: wenjuan@mail.shu.edu.cn
Supported by:
the Key Projects of National Natural Science Foundation of China (No.11932010)

摘要/Abstract

摘要： Explaining the mechanism of the cochlear active phonosensitive amplification has been a major problem in medicine. The basilar membrane (BM) is the key infrastructure. In 1960, Nobel Laureate von Békésy first discovered BM's traveling wave motion. Since that time, BM's models only have considered the traveling wave but not the biological activity. Therefore, a new model considering changes of BM's stiffness in space and time is established based on the immersed boundary method to describe its biological activity. It not only reproduces the results of traveling wave motion but also explains the mechanization on the generation of traveling wave. An important discovery is that changes of BM's stiffness in space and time will cause the unstable global resonance, which will induce amplification of sounds in cochlea. An important inference is that biological activity shall be included in the application of mechanical principles to the analysis of life, which is the essential difference between biomechanics and general mechanics.

关键词: basilar membrane (BM), biological activity, mechanical analysis, cochlear phonosensitive amplification

Abstract: Explaining the mechanism of the cochlear active phonosensitive amplification has been a major problem in medicine. The basilar membrane (BM) is the key infrastructure. In 1960, Nobel Laureate von Békésy first discovered BM's traveling wave motion. Since that time, BM's models only have considered the traveling wave but not the biological activity. Therefore, a new model considering changes of BM's stiffness in space and time is established based on the immersed boundary method to describe its biological activity. It not only reproduces the results of traveling wave motion but also explains the mechanization on the generation of traveling wave. An important discovery is that changes of BM's stiffness in space and time will cause the unstable global resonance, which will induce amplification of sounds in cochlea. An important inference is that biological activity shall be included in the application of mechanical principles to the analysis of life, which is the essential difference between biomechanics and general mechanics.

Key words: basilar membrane (BM), biological activity, mechanical analysis, cochlear phonosensitive amplification

中图分类号:

92B05

J.Y. LIANG, Wenjuan YAO. Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification[J]. Applied Mathematics and Mechanics (English Edition), 2023, 44(5): 823-840.

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Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

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