Abstract: In this paper, a new notion of a generalized H-η-accretive operator is introduced and studied, which provides a unifying framework for the generalized m-accretive operator and the H-η-monotone operator in Banach spaces. A resolvent operator associated with the generalized H-η-accretive operator is defined, and its Lipschitz continuity is shown. As an application, the solvability for a class of variational inclusions involving the generalized H-η-accretive operators in Banach spaces is considered. By using the technique of the resolvent mapping, an iterative algorithm for solving the variational inclusion in Banach spaces is constructed. Under some suitable conditions, it is proven that the solution for the variational inclusion and the convergence of the iterative sequence generated by the algorithm exist.