Numerical simulation of magnetic drug targeting with Eulerian-Lagrangian model and effect of viscosity modification due to diabetics

doi:10.1007/s10483-016-2145-8

Applied Mathematics and Mechanics (English Edition) ›› 2016, Vol. 37 ›› Issue (12): 1631-1646.doi: https://doi.org/10.1007/s10483-016-2145-8

Numerical simulation of magnetic drug targeting with Eulerian-Lagrangian model and effect of viscosity modification due to diabetics

M. M. LARIMI, A. RAMIAR, A. A. RANJBAR

Faculty of Mechanical Engineering, Babol Noshirvani University of Technology, Babol 47148-71167, Iran

收稿日期:2016-01-30 修回日期:2016-07-15 出版日期:2016-12-01 发布日期:2016-12-01
通讯作者: A. RAMIAR E-mail:aramiar@nit.ac.ir

Numerical simulation of magnetic drug targeting with Eulerian-Lagrangian model and effect of viscosity modification due to diabetics

M. M. LARIMI, A. RAMIAR, A. A. RANJBAR

Faculty of Mechanical Engineering, Babol Noshirvani University of Technology, Babol 47148-71167, Iran

Received:2016-01-30 Revised:2016-07-15 Online:2016-12-01 Published:2016-12-01
Contact: A. RAMIAR E-mail:aramiar@nit.ac.ir

摘要/Abstract

摘要：

The targeted drug delivery and targeted drug therapy transport a drug directly to the center of the disease under various conditions and thereby treat it deliberately without effects on the body. This paper studies the magnetic drug targeting (MDT) technique by particle tracking in the presence of magnetic field in bifurcation vessels of a healthy person and a diabetes patient. The Lagrangian particle tracking is performed to estimate particle behavior under effects of imposed magnetic field gradients along the bifurcation. The results show that the magnetic field increases the volume fraction of particle in the target region, and the efficiency of MDT on a patient with the diabetes disease is better than a healthy person. Also, for the higher magnetic numbers, the flow in the upper branch is strongly affected by the magnetic field.

关键词: magnetic nano-particles, Lagrangian method, bifurcation, particle tracking

Abstract:

Key words: bifurcation, Lagrangian method, particle tracking, magnetic nano-particles

中图分类号:

76D05

M. M. LARIMI, A. RAMIAR, A. A. RANJBAR. Numerical simulation of magnetic drug targeting with Eulerian-Lagrangian model and effect of viscosity modification due to diabetics[J]. Applied Mathematics and Mechanics (English Edition), 2016, 37(12): 1631-1646.

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Numerical simulation of magnetic drug targeting with Eulerian-Lagrangian model and effect of viscosity modification due to diabetics

Numerical simulation of magnetic drug targeting with Eulerian-Lagrangian model and effect of viscosity modification due to diabetics

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